Royal Air Force Typhoon FGR4s have joined forces with French warplanes in a joint strike on an underground arms cache in Syria operated by the IS group, as stated by the British defence ministry.
The facility, identified by surveillance, was thought to be housing weapons and explosive materials, the release indicated, and was located in mountains just above Palmyra in the heart of Syria.
"Our aircraft employed precision-guided Paveway IV munitions to strike a number of approach shafts leading to the facility... early reports suggest the strike was effective," the MoD said.
There was no evidence of any civilian casualties in the strike late on Saturday and each participating jet made a safe return, the MoD added.
The Typhoon FGR4s were supported by a Voyager tanker plane.
IS - referred to as the so-called Islamic State - imposed jihadist rule over parts of Iraq and Syria until 2019.
"This strike shows our UK leadership, and commitment to operate in unison with allied nations, to stamp out any re-emergence of the terrorist group and their dangerous and violent ideologies in the area," UK Defence Secretary the Defence Secretary said.
British military aircraft have carried out surveillance missions over Syria to "deter any attempted comeback" of IS after its routing at the climactic battle in Baghuz in the year 2019, the ministry said.
"I must thank every member of British forces involved in this strike for their skill and their courage," he added. "Including them were numerous UK service members stationed over the holidays. This action, to remove militants who pose a risk to our security, demonstrates how our armed forces are ready to step up, all year round, ensuring Britain's security within its borders and powerful internationally."
During December, the United States armed forces conducted what it termed a "large-scale strike" on IS targets in Syria, after an ambush resulted in the deaths of two American soldiers and a civilian interpreter in Palmyra.
The United Nations estimates Daesh still has between 5,000 and 7,000 fighters in both countries.